BioPharma Dive asked top thought leaders to share what they considered to be the top biopharma "game-changers" of 2015. "A major game-changer in 2015 was increasing price pressure on prescription drugs in the U.S. market coming from a rapidly consolidating customer case (payers/PBMs, providers and channel)," said Ashish Singh, the leader of Bain & Company's Global Healthcare practice. "This trend is now starting to endanger the economic lifeblood of the global pharmaceutical industry—the premium price reimbursement in the U.S."