To strengthen economic and innovation power, Germany has to set-up regional clusters. Decisive factors are: financial support for R&D, local network of innovative founders and well established companies, Venture Capitalists, politics and science. Moreover, high-skilled graduates, local industry and an attractive location marketing is essential. To belong to the top clusters in the world, extraordinary entrepreneurial success stories that are closely connected with the location are needed. Bain & Company has compared the world-wide clusters Silicon Valley, Boston, Cambridge, Sophia Antiopolis and Tel Aviv and analyzed their keys to success.